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Genz 669178
CAS No. 1254834-91-7
Genz 669178 ( Genz669178 )
产品货号. M11036 CAS No. 1254834-91-7
A potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
|
| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Genz 669178
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.
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产品描述A potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei; demonstrates in vitro potency against the 3D7 and Dd2 strains of P. falciparum, good tolerability and oral exposure in the mouse, and ED(50) values in the 4-day murine P. berghei efficacy model of 13-21 mg/kg/day with oral twice-daily dosing.
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同义词Genz669178
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通路GPCR/G Protein
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靶点Antibacterial
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受体Antibacterial
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研究领域——
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适应症——
化学信息
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CAS Number1254834-91-7
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分子量322.39
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分子式C17H14N4OS
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1=CC=C(N2C3=CC=CC(C#N)=C3N=C2C)S1)NC4CC4
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化学全称5-(4-cyano-2-methyl-1H-benzo[d]imidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lukens AK, e tal. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804.
2. Booker ML, et al. J Biol Chem. 2010 Oct 22;285(43):33054-64.
3. Skerlj RT, et al. ACS Med Chem Lett. 2011 Jul 11;2(9):708-13.
2. Booker ML, et al. J Biol Chem. 2010 Oct 22;285(43):33054-64.
3. Skerlj RT, et al. ACS Med Chem Lett. 2011 Jul 11;2(9):708-13.
产品手册
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